Generic Name:
Permethrin

Composition:
• Each gram of Permicure 5% Cream contains Permethrin BP 50 mg.

Pharmacology:
• Permethrin is a topical scabicidal agent used for the treatment of scabies infestation.
• It acts on the nervous system of insects, primarily by disrupting sodium channels in nerve cell membranes, resulting in paralysis of the insect nerve cells.

Indications:
• Treatment of scabies.
• Treatment of lice infestations (Pediculosis).

Dosage & Administration:
• Apply the cream to clean, dry, cool skin.
• If the patient has taken a warm bath before treatment, allow the skin to cool before applying the cream.
• Apply to the whole body, excluding the head, as directed in the approved product insert.
• Avoid contact with the eyes and areas around the mouth.
• The whole body should be washed thoroughly 8–12 hours after treatment.
• If any area of the body is washed with soap and water during the treatment period, reapply the cream to that area.
• Adults and children over 12 years: Up to 30 g may be used as a single application. Some adults may require more than 30 g for complete body coverage, but not more than 60 g should be used in a single application.
• Children aged 6–12 years: Up to half a tube.
• Children aged 1–5 years: Up to one-quarter of a tube.
• Children aged 2 months to 2 years should be treated under medical supervision.
• Approximately 90% of individuals are cured with a single application. If necessary, a second application may be given no sooner than 7 days after the initial application if the original lesions are not healing or new lesions appear.
• All members of the affected household should be treated simultaneously.
• The dose for children aged 2 months to 1 year must be confirmed against the approved product insert before publication. The dose for children under 2 months is not established in the supplied insert.

Contraindications:
• Contraindicated in individuals with a known allergy to permethrin, any of its components, other pyrethroids, or pyrethrins.

Side Effects:
• Skin discomfort, including burning, may occur after application.
• Temporary erythema, edema, eczema, and rash may occur.

Precautions:
• Permethrin may irritate the eyes. Avoid contact with the eyes.
• When applying the cream to children’s faces, take care around the eyes and mouth to prevent the cream from being licked off.
• Nursing staff who routinely come into contact with the cream may wear gloves to avoid possible hand irritation.

Drug Interactions:
• According to the supplied insert, treatment of eczema-like diseases with corticosteroids should be discontinued during Permicure application, as this may increase the incidence of itching due to loss of protective activity against microbes.

Use in Pregnancy & Lactation:
• During pregnancy, use only on medical advice.
• The supplied insert states that it is not known whether permethrin is excreted in human milk and that it should not be used in nursing mothers.

Overdose:
• No reports of overdosage with Permicure Cream are stated in the supplied insert.

Storage:
• Store below 30°C, protected from light and moisture.
• Store in a dry and cool place.
• Keep out of reach of children.

Dosage Form:
• Cream.

Commercial Packaging:
• Each pack contains one 30 g cream-filled laminate tube.